Since many years, the interest of our lab is focused on the role of UHRF1 (alias Np95 or ICBP90) and its close structural homologue UHRF2, in DNA methylation and in the epigenetic regulation of onco-suppressors during tumour progression. The SRA (Set and RING-finger-associated domain) domain containing protein UHRF1 is master epigenetic regulator and transcriptional repressor essential to maintain global and local DNA methylation and required for the epithelial to mesenchimal transition (EMT) in tumours.
Staff and contacts
- prof. Ian Marc Bonapace
- dr. Monica Mancini
Find us: via Manara 7, 21052 Busto Arsizio, Varese