Laboratorio
Biomaterials Laboratory
Sito web personale
www.biomatlab.it
Group leaders:
Maria Cristina Tanzi (Full Professor of Biomaterials)
keywords
- biomaterials design;
- tissue engineering;
- scaffold characterization;
- in vitro and in vivo biocompatibility;
- surface modification;

Collaboratori
Silvia Farč (Assistant Professor)
Paola Petrini (Assistant Professor)
Sabrina Bozzini (Research Fellow)
Lina Altomare (Research Fellow)
Valentina Catto (Research Fellow)
Liliana Giuliano (Research Fellow)
Serena Bertoldi (Ph.D. Student)
Fabiola Munarin (Ph.D. Student)

Linee di ricerca
- Design and synthesis of innovative polymers, in particular elastomeric materials, foams and hydrogels, and composites for applications into the human body, elastomers for cardiovascular devices, hydrogels and injectable microcapsules for drug delivery, scaffolds for tissue engineering;
- Mechanical and physico-chemical characterization of biomaterials and scaffolds, analysis of degradation phenomena after processing, sterilization and in vivo implantation;
- Surface modification to promote specific biological responses;
- Study and characterization of smart and shape memory materials;
- Study of the in vitro and in vivo interactions of biomaterials with proteins, cells and tissues;
- Guidelines and protocols definition for polymeric biomaterials characterization and design of implantable devices;
Struttura di appartenenza
Biomaterials Laboratory
Dept. of Bioengineering
Politecnico di Milano
Piazza Leonardo da Vinci 32 – 20133 Milano
02 23993362 – mariacristina.tanzi@polimi.it

Expertise
- Synthesis of polymeric materials: synthesis of polyurethanes and composites for biomedical applications and for tissue engineering;
- Materials characterization: expertise in optical microscopy, SEM, ESEM and AFM analyses and Differential Scanning Calorimetry (DSC), mechanical characterization by compressive or tensile tests, dynamic mechanical analysis (DMA), high performance chromatography (HPLC), Fourier-transformed Infrared spectrometry (FT-IR) with ATR accessory for surface analysis;
- In vitro biocompatibility: expertise in in vitro cellular assays with several cell lines to evaluate materials cytocompatibility and cell interaction with scaffold;
- Surface modifications: design of surface with antibacterial activity, surface modification (soft lithography technique and microcontact printing of specific proteins) of biodegradable polymeric substrates to evaluate cells response to microstructured surfaces;

1. Zanetta M., Quirici N., Demarosi F., Tanzi M.C., Rimondini L., Farč S., Ability of polyurethane foams to support cell proliferation and the differentiation of MSCs into osteoblasts. Acta Biomater 2009; 5: 1126-1136.
2. Marelli B., Alessandrino A., Farč S., Tanzi M.C., Freddi G., Electrospun silk fibroin tubular matrixes for small vessel bypass grafting. Materials Technology 2009; 24 (1): 52-57.
3. Altomare L., Farč S., Cells response to topographic and chemical micropatterns. Journal of Applied Biomaterials & Biomechanics 2008; 6 (3): 132-143.
4. Pitarresi G., Palumbo F.S., Cavallaro G., Farč S., Giammona G., Scaffolds based on hyaluronan crosslinked with a polyaminoacid: Novel candidates for tissue engineering application. J Biomed Mater Res 2008; 87A:770–779.
5. Petrini P, Arciola C.R., Pezzali I., Bozzini S., Montanaro L., Tanzi M.C., Speziale P., Visai L., Antibacterial activity of zinc modified titanium oxide surface. Int J Artif Organs. 2006; 29(4): 434-42